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Authors should present the significance and conceptual advance of their work in a clear and accessible way to a broad readership. The initial data, the methods, findings and references should be presented in such a way to allow others to replicate the studies. Fraudulent and knowingly inacurrate statements represent unethical behaviour and are unacceptable. The authors should ensure that their work is entirely original, any part of the work or words belonging to other works should be acknowledged. All citations in the text, figures or tables must be found in the reference list and vice-versa. Duplicate submission or plagiarism are considered unethical and are unacceptable. The corresponding author should request full consensus from all co-authors for the submitting for publication of the final version of the manuscript.